STUDY OF BIOACTIVE BIORESORBABLE POLYMER MATRICES BY RAMAN SPECTROSCOPY

Abstract

Raman spectroscopy technique for analysis of spatial distribution and release kinetics of bioactive substances from bioresorbable polymeric matrixes and particles have been developed and applied. The distribution of hydroxyapatite microparticles in polylactide particles was studied. The release kinetics of ibuprofen from polylactoglycolide matrices of different porosity is analyzed. The dependence of the concentration test substance which released from the polymer matrix on the time of its presence in solution in the range from several hours to several days was studied. The main advantages of the developed methods are the universality of their applicability for studying the structures of various bioactive polymeric composites and their behavior in water-containing media in situ without destroying the analyzed samples, and also the absence of the need for using complex procedures for sample preparation