SPECTROSCOPY OF COMBINATION SCATTERING OF THE LIGHT FOR BLOOD SERUM IN PATIENTS WITH COLORECTAL CANCER WITH VARIOUS LOCALIZATION OF METASTASES (PILOT STUDY)
https://doi.org/10.25205/2541-9447-2018-13-2-95-100
Abstract
The spectra of combination scattering of the light (Raman) for samples of liquid serum in 68 people were studied: 19 conditionally healthy persons without oncological pathology and 49 people with colorectal cancer (divided into 3 groups depending on the localization of metastases) with the goal of determining the possibility of using Raman-spectroscopy for liquid serum in differentiating patients with colorectal cancer (CRC) with a various localization of metastases. The intensity of the peaks at 1005, 1157 and 1520 cm-1 in Raman spectra in patients with CRC compared with healthy individuals turned out to be significantly lower, correlating with the stage of the disease and the presence of metastases, which makes it possible to treat serum by Raman-spectroscopy as a promising diagnostic approach in colorectal cancer, in including at the early stages of the development of the disease. The diagnostic accuracy of this method in performing ROC analysis in differentiating local-regional CRC from metastatic was AUC 0.91 (0.82; 0.95) (95 % confidence interval), in distinguishing patients with liver metastases from those extrahepatic - AUC 0.73.
About the Authors
M. V. Kruchinina
Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics SB RAS; Novosibirsk State Medical University
Russian Federation
Russian Federation
V. N. Kruchinin
Rzhanov Institute of Semiconductor Physics SB RAS
Russian Federation
Russian Federation
V. A. Volodin
Rzhanov Institute of Semiconductor Physics SB RAS
Russian Federation
Russian Federation
Ya. I. Prudnikova
Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics SB RAS
Russian Federation
Russian Federation
A. A. Gromov
Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics SB RAS
Russian Federation
Russian Federation
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Review
For citations:
Kruchinina M.V., Kruchinin V.N., Volodin V.A., Prudnikova Ya.I., Gromov A.A. SPECTROSCOPY OF COMBINATION SCATTERING OF THE LIGHT FOR BLOOD SERUM IN PATIENTS WITH COLORECTAL CANCER WITH VARIOUS LOCALIZATION OF METASTASES (PILOT STUDY). SIBERIAN JOURNAL OF PHYSICS. 2018;13(2):95-100. (In Russ.) https://doi.org/10.25205/2541-9447-2018-13-2-95-100
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