A Neutron Beam Shaping Assembly for Boron Neutron Capture Therapy of Superficial Tumors
https://doi.org/10.25205/2541-9447-2023-18-3-31-42
Abstract
The Vacuum Insulated Tandem accelerator have been developed in Budker Institute of Nuclear Physics. Neutrons are generated in 7Li(p,n)7Be reaction. Neutron beam shaping assembly is used for therapeutic beam forming. It consists of the moderator, reflector and filter. Magnesium fluoride is considered optimal material for neutron slowing down because of noticeable cross section of inelastic neutron scattering. Previously, we showed that it is optimal to use proton beam at energy 2.3 MeV for neutron generation.
As a result of a critical analysis of our earlier decisions on the methods used to form a therapeutic neutron beam and decisions of other research groups, as well as successful experiments on the irradiation of laboratory pets and cell cultures carried out at our experimental facility, we noticed that with the recent trend towards a decrease in proton energy the process of inelastic scattering in MgF2 is no longer decisive in neutron moderation, and it was decided to consider materials based on plexiglass as a moderator material.
In this work we considered Poly-Biz as moderator material and get the neutron beam the same quality as with MgF2 moderator and proton energy 2.3 MeV but at lower proton energy and current that can cause treatment time reducing and allows more reliable neutron generation.For a long time, the development of BNСT was hindered by the lack of charged particle accelerators that provide stable production of a stationary 2.5 MeV 10 mA proton beam. The use of BSA with Poly-Biz allows the use of these accelerators at lower energy, which improves the reliability of their operation, and reduces the therapy time by more than 2 times, which is also important for therapy. Also, the use of such an BSA simplifies the requirements for a charged particle accelerator and this opens up both the possibility of optimizing the developed accelerators and the use of other accelerators that have not yet reached the required parameters.
Supporting agencies: This research was funded by the Russian Science Foundation (project No. 19-72-30005).
About the Authors
Т. V. Sycheva
Budker Institute of Nuclear Physics; Novosibirsk State University
Russian Federation
Russian Federation
Tatiana V. Sycheva, Researcher
Novosibirsk
Е. А. Berendeev
Budker Institute of Nuclear Physics; Novosibirsk State University
Russian Federation
Russian Federation
Evgeny A. Berendeev, Candidate of Physical and Mathematical Sciences
Novosibirsk
G. D. Verkhovod
Budker Institute of Nuclear Physics; Novosibirsk State University
Russian Federation
Russian Federation
Gleb D. Verkhovod, Postgraduate Student
Novosibirsk
S. Yu. Taskaev
Budker Institute of Nuclear Physics; Novosibirsk State University
Russian Federation
Russian Federation
Sergey Yu. Taskaev, Doctor of Physical and Mathematical Sciences
Novosibirsk
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Review
For citations:
Sycheva Т.V., Berendeev Е.А., Verkhovod G.D., Taskaev S.Yu. A Neutron Beam Shaping Assembly for Boron Neutron Capture Therapy of Superficial Tumors. SIBERIAN JOURNAL OF PHYSICS. 2023;18(3):31-42. (In Russ.) https://doi.org/10.25205/2541-9447-2023-18-3-31-42
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